Risako Kon

Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

Risako Kon, Nobutomo Ikarashi, Chika Nagoya et al. · Journal of Ethnopharmacology · 2014 · 107 citations

Inflammation, Rhubarb Extract, Anti-inflammatory +8

The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE₂secretion from macrophages

Nobutomo Ikarashi, Kohta Baba, Takashi Ushiki et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2011 · 95 citations

Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion

Risako Kon, Nobutomo Ikarashi, Akio Hayakawa et al. · Toxicological Sciences · 2015 · 93 citations

Morphine-induced Constipation, Gastrointestinal Pharmacology, Oral Morphine Administration +19

Relationship between Aging-Related Skin Dryness and Aquaporins

Nobutomo Ikarashi, Risako Kon, Miho Kaneko et al. · International Journal of Molecular Sciences · 2017 · 65 citations · Full text

Inflammation, Molecular Physiology, Aging +12

Inhibition of Aquaporin-3 Water Channel in the Colon Induces Diarrhea

Nobutomo Ikarashi, Risako Kon, Tomohiko Iizasa et al. · Biological and Pharmaceutical Bulletin · 2012 · 60 citations · Full text

Inflammation, Fecal Water Content, Osmotic Stress +13