Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

Luigi Fontana, Nicole E. Cummings, Sebastian I. Arriola Apelo, +21

Cell Reports

The effects of graded caloric restriction: <scp>XII</scp>. Comparison of mouse to human impact on cellular senescence in the colon

Luigi Fontana, Sharon E. Mitchell, Boshi Wang, +8

Aging Cell

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

Ryan O. Walters, Esperanza Arias, Antonio Díaz, +18

Cell Reports

InflammationNutritionAgingLongevityMedicine +9

In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles

Erez Eitan, Valeria Tosti, Caitlin N. Suire, +11

Aging Cell

Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution

Nico A. Contreras, Luigi Fontana, Valeria Tosti, +1

GeroScience

InflammationCaloric RestrictionAutoimmune DiseasePhysiologyImmunology +8

Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and –independent mechanisms

J. Humberto Treviño-Villarreal, Justin S. Reynolds, Alexander Bartelt, +22

JCI Insight

NutritionCaloric RestrictionProtein RestrictionOxidative StressObesity +19

Excess body weight increases the burden of age-associated chronic diseases and their associated health care expenditures

Vincenzo Atella, Joanna Kopinska, Gerardo Medea, +5

Aging

Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer’s Disease

Farzaneh Rahmani, Laura Ghezzi, Valeria Tosti, +9

Journal of Alzheimer s Disease

Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults

Marco Demaria, Beatrice Bertozzi, Nicola Veronese, +6

npj Aging

Physical ActivityAgingCell DeathPathologyBiogerontology +18

Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis

Laura Ghezzi, Valeria Tosti, Lisa Shi, +23

Journal of Neurology Neurosurgery & Psychiatry