R. Adam

Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis

R. Adam, Isabel Spier, Bixiao Zhao et al. · The American Journal of Human Genetics · 2016 · 249 citations · Full text

Medicine, Genetics, Molecular Genetics +14

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Kristiaan Lenos, Daniël M. Miedema, Sophie C. Lodestijn et al. · Nature Cell Biology · 2018 · 172 citations · Full text

Medicine, Cancer Biology, Oncology +17

Frequency and phenotypic spectrum of germline mutations in <scp><i>POLE</i></scp> and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas

Isabel Spier, Stefanie Holzapfel, Janine Altmüller et al. · International Journal of Cancer · 2014 · 139 citations · Full text

Medicine, Genetics, Molecular Genetics +17

Genome‐wide CNV analysis in 221 unrelated patients and targeted high‐throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis

Sukanya Horpaopan, Isabel Spier, Alexander M. Zink et al. · International Journal of Cancer · 2014 · 65 citations · Full text

Medicine, Genetics, Molecular Genetics +17

Low-level <i>APC</i> mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases

Isabel Spier, Dmitriy Drichel, Martin Kerick et al. · Journal of Medical Genetics · 2015 · 65 citations · Full text

Medicine, Genetics, Oncology +17