Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Stephen C. Mack, Kristian W. Pajtler, Lukas Chávez, +72

Nature

OncologyNovel TherapyOncogenic AgentMedicinePathology +5

N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

Xinzi Yu, Tobias Zech, Laura McDonald, +16

The Journal of Cell Biology

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

Juan R. Hernández‐Fernaud, Elena Ruengeler, Andrea Casazza, +26

Nature Communications

Tumor BiologyOncologyCaf SecretomeOncogenic AgentMedicine +13

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

Vanessa M. D’Costa, Virginie Braun, Marija Landekic, +6

Cell Reports

Microbial PathogensMolecular BiologyPathogen EffectorCytoskeletonMicrotubule Motors +19

Runx2 in normal tissues and cancer cells: A developing story

Karen Blyth, François Vaillant, Alma Jenkins, +6

Blood Cells Molecules and Diseases

Tumor BiologyMedicinePathologyCell ProliferationCancer Cells +4

MNK Inhibition Sensitizes <i>KRAS</i> -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

John R. P. Knight, Constantia Alexandrou, George Skalka, +36

Cancer Discovery

High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers

Matthew Brimmell, Jorge S. Burns, Philippa Munson, +4

British Journal of Cancer

RUNX2 in subtype specific breast cancer and mammary gland differentiation

Laura McDonald, Nicola Ferrari, Anne Terry, +11

Disease Models & Mechanisms

RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Nicholas Rooney, Susan Mason, Laura McDonald, +12

Cancer Research

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Mathieu Unbekandt, Simone Belshaw, Justin Bower, +26

Cancer Research