Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19

Junjie T. Hua, Musaddeque Ahmed, Haiyang Guo, +20

Cell

GeneticsGene RegulationCancer GenomicsLong Non-coding RnaProstatic Disease +4

Nucleolar RNA polymerase II drives ribosome biogenesis

Karan Joshua Abraham, Negin Khosraviani, Janet N.Y. Chan, +22

Nature

Transcriptional RegulationRibosome BiogenesisRna BiologyRna TransportGene Expression +3

Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia

Samir H. Barghout, Parasvi S. Patel, Xiaoming Wang, +18

Leukemia

Hematological MalignancyPreclinical EvaluationAcute Myeloid LeukemiaMedicineHematology +8

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Geethu Emily Thomas, Grace Egan, Laura García‐Prat, +24

Nature Cell Biology

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

Parasvi S. Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, +24

Journal of Clinical Investigation

Tumor BiologyTranscriptional RegulationGenome InstabilityMedicineR-loop Resolution +13

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, +13

Nature Communications

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

Li Li, Kiran Kumar Naidu Guturi, Brandon Gautreau, +20

Journal of Clinical Investigation

Breast OncologyCancer BiologyMammary Gland DevelopmentTumor BiologyTranscriptional Regulation +15

Unprocessed genomic uracil as a source of DNA replication stress in cancer cells

Sneha Saxena, Christopher S. Nabel, Turner W. Seay, +9

Molecular Cell

ChromatinGenome InstabilityOncogenic AgentNatural SciencesGenetics +10

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ

Haibo Yang, Emily M. Lachtara, Xiaojuan Ran, +9

Nature Communications

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

Wendy Leung, Antoine Simoneau, Sneha Saxena, +5

Cell Reports