Isaac A. Chaim

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

Cleber A. Trujillo, Richard Gao, Priscilla D. Negraes et al. · Cell stem cell · 2019 · 887 citations · Full text

Developmental Biology, Neurodynamics, Brain Structure +14

Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9

Ranjan Batra, David A. Nelles, Elaine Pirie et al. · Cell · 2017 · 254 citations · Full text

Genetics, Genetic Engineering, Molecular Biology +7

Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes

Kristopher W. Brannan, Isaac A. Chaim, Ryan J. Marina et al. · Nature Methods · 2021 · 176 citations · Full text

Engineering, Molecular Biology, Rna-binding Proteins +16

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

Jaclyn M. Einstein, Mark Perelis, Isaac A. Chaim et al. · Molecular Cell · 2021 · 175 citations · Full text

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

Zachary D. Nagel, Carrie M. Margulies, Isaac A. Chaim et al. · Proceedings of the National Academy of Sciences · 2014 · 167 citations · Full text