Wendy Clarke

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

James R. Burke, Mark A. Pattoli, Kurt R. Gregor et al. · Journal of Biological Chemistry · 2003 · 547 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Discovery of a 1<i>H</i>-Benzoimidazol-2-yl)-1<i>H</i>-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Mark D. Wittman, Joan M. Carboni, Ricardo M. Attar et al. · Journal of Medicinal Chemistry · 2005 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors

Guanglin Luo, Ling Chen, Catherine R. Burton et al. · Journal of Medicinal Chemistry · 2016 · 71 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- <scp>d</scp>-glucopyranosyl]-5<i>H</i>,13<i>H</i>-benzo[<i>b</i>]- thienyl[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole- 5,7(6<i>H</i>)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

Balu Balasubramanian, Denis R. St. Laurent, Mark G. Saulnier et al. · Journal of Medicinal Chemistry · 2004 · 36 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Synthesis and structure–activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors

Makonen Belema, Amy Bunker, Van N. Nguyen et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11