IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Samuel Huber, Nicola Gagliani, Lauren A. Zenewicz, +14

Nature

InflammationCytokineMucosal ImmunologyImmunologyPathology +6

Chronic stimulation of Nod2 mediates tolerance to bacterial products

Matija Hedl, Jing Li, Judy H. Cho, +1

Proceedings of the National Academy of Sciences

Innate Immune SystemBacteriologyImmunologyImmune RegulationToll-like Receptor +17

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, +191

Nature Communications

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation

Matija Hedl, Jie Yan, Clara Abraham

Cell Reports

ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation

Michael A. Schumacher, Matija Hedl, Clara Abraham, +8

Cell Death and Disease

Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

Amit Lahiri, Matija Hedl, Jie Yan, +1

Nature Communications

<i>Enterococcus faecalis</i> Acetoacetyl-Coenzyme A Thiolase/3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, a Dual-Function Protein of Isopentenyl Diphosphate Biosynthesis

Matija Hedl, Autumn Sutherlin, E. Imogen Wilding, +8

Journal of Bacteriology

Microbial PathogensBacteriologyBacterial PathogensBiosynthesisStructure-function Enzyme Kinetics +15

Pattern Recognition Receptor Signaling in Human Dendritic Cells is Enhanced by ICOS Ligand and Modulated by the Crohn’s Disease ICOSLG Risk Allele

Matija Hedl, Amit Lahiri, Kaida Ning, +2

Immunity

Chronic Inflammatory DiseasesImmune RegulationImmunologyImmune SystemInflammation +14

Secretory Mediators Regulate Nod2-Induced Tolerance in Human Macrophages

Matija Hedl, Clara Abraham

Gastroenterology

InflammationSignal TransductionHuman MacrophagesAutophagyImmunology +5

A <i>TNFSF15</i> disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8–induced IL-1

Matija Hedl, Clara Abraham

Proceedings of the National Academy of Sciences

Immune RegulationImmunologyGenetic EpidemiologyPathologyImmune System +17