Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

Lucia Di Marcotullio, Elisabetta Ferretti, Azzura Greco, +8

Nature Cell Biology

Targets Gli1Signal TransductionDevelopmental BiologyItch-dependent UbiquitinationSignaling Pathway +4

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

Alessandra Vacca, María Pía Felli, Antonietta R. Farina, +7

The Journal of Experimental Medicine

ImmunologyImmune RegulationGlucocorticoidGlucocorticoid ReceptorCellular Physiology +17

REN ^KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

Lucia Di Marcotullio, Elisabetta Ferretti, Enrico De Smaele, +12

Proceedings of the National Academy of Sciences

Lineage PlasticityDevelopmental BiologyHedgehog SignalingHuman MedulloblastomaCell Regulation +12

Transcriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elements.

Antonietta R. Farina, Antonella Tacconelli, Alessandra Vacca, +3

PubMed

Tumor InnervationParticular Mmp-9Cancer BiologyTumor BiologyNeuro-oncology +20

Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma

Enrico De Smaele, Lucia Di Marcotullio, Marta Moretti, +14

Neoplasia

Kctd ContainingChromatinDevelopmental BiologySignaling PathwayGlioma +9

Testicular development involves the spatiotemporal control of PDGFs and PDGF receptors gene expression and action.

Lucio Gnessi, A Emidi, Emmanuele A. Jannini, +5

The Journal of Cell Biology

SpermatogenesisHuman GrowthGeneticsCell ProliferationReproductive Biology +18

Expression of trKB neurotrophin receptor during T cell development. Role of brain derived neurotrophic factor in immature thymocyte survival

Marella Maroder, Diana Bellavia, Daniela Meco, +8

The Journal of Immunology

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, +17

Cell Death and Disease

Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences.

Alessandra Vacca, Stefano Martinotti, Isabella Screpanti, +7

Journal of Biological Chemistry

T-regulatory CellImmunologyImmunologic MechanismGlucocorticoidGlucocorticoid Receptor +17

Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice.

Isabella Screpanti, Piero Musiani, Diana Bellavia, +7

The Journal of Experimental Medicine

ImmunologyCell DeathPathologyImmunologic MechanismImmune System +18