Geoffrey Li

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy

Cristina Olivieri, Geoffrey Li, Yingjie Wang et al. · Science Advances · 2022 · 57 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +16

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle

Yingjie Wang, Manu Veliparambil Subrahmanian, Jonggul Kim et al. · Nature Communications · 2019 · 56 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Cristina Olivieri, Yingjie Wang, Geoffrey Li et al. · eLife · 2020 · 33 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Ion mobility–mass spectrometry reveals the role of peripheral myelin protein dimers in peripheral neuropathy

Sarah M. Fantin, Kristine F. Parson, Pramod Kumar Yadav et al. · Proceedings of the National Academy of Sciences · 2021 · 33 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

Michael D. Tomasini, Yingjie Wang, Adak Karamafrooz et al. · Scientific Reports · 2018 · 29 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17