Cristina Olivieri

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

Caitlin Walker, Yingjie Wang, Cristina Olivieri et al. · Science Advances · 2019 · 66 citations · Full text

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

John T. Happ, Corvin D. Arveseth, Jessica Bruystens et al. · Nature Structural & Molecular Biology · 2022 · 59 citations · Full text

Hedgehog Signal Transduction, Developmental Biology, Molecular Physiology +7

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy

Cristina Olivieri, Geoffrey Li, Yingjie Wang et al. · Science Advances · 2022 · 51 citations · Full text

Conformational Entropy, Protein Assembly, Biochemistry +14

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Cristina Olivieri, Yingjie Wang, Geoffrey Li et al. · eLife · 2020 · 33 citations · Full text

Protein Assembly, Signal Recognition, Molecular Biology +22

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Cristina Olivieri, Caitlin Walker, Adak Karamafrooz et al. · Communications Biology · 2021 · 28 citations · Full text