Lauryn Samelko

Increasing both CoCrMo‐alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

Marco S. Caicedo, Lauryn Samelko, Kyron McAllister et al. · Journal of Orthopaedic Research® · 2013 · 117 citations · Full text

Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure

Lauryn Samelko, Marco S. Caicedo, Seung‐Jae Lim et al. · PLoS ONE · 2013 · 63 citations · Full text

Mechanobiology, Artificial Hip Implants, Engineering +11

Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

Lauryn Samelko, Stefan Landgraeber, Kyron McAllister et al. · PLoS ONE · 2016 · 56 citations · Full text

Innate Immune System, Immunology, Immune Regulation +28

Implant Debris Particle Size Affects Serum Protein Adsorption Which May Contribute to Particle Size-Based Bioreactivity Differences

Anand Reddy, Marco S. Caicedo, Lauryn Samelko et al. · Journal of Long-Term Effects of Medical Implants · 2014 · 17 citations · Full text

Tissue Engineering, Orthopaedic Biomaterials, Size-based Bioreactivity Differences +12

TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles

Lauryn Samelko, Stefan Landgraeber, Kyron McAllister et al. · Journal of Orthopaedic Research® · 2016 · 16 citations · Full text

Innate Immune System, Immunology, Immune Regulation +19