Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

Wenning Qin, Stephanie Dion, Peter M. Kutny, +7

Genetics

Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure

Wenning Qin, Amy E. Rudolph, Brian R. Bond, +5

Circulation Research

Design and testing of a humanized porcine donor for xenotransplantation

R. Anand, Jacob V. Layer, Dávid Héja, +56

Nature

Extensive germline genome engineering in pigs

Yanan Yue, Weihong Xu, Yinan Kan, +39

Nature Biomedical Engineering

Developmental BiologyXenotransplantationEngineeringGeneticsSynthetic Biology +8

ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization

Anne‐Marie Malfait, Jennifer Ritchie, Alexis S.C. Gil, +5

Osteoarthritis and Cartilage

MechanobiologyMechanical AllodyniaMusculoskeletal ResearchEngineeringDegenerative Diseases +11

Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques

Dávid Ma, Takayuki Hirose, Grace Lassiter, +19

American Journal of Transplantation

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease

Tatsuo Kawai, Winfred W. Williams, Nahel Elias, +35

New England Journal of Medicine

UrologyXenotransplantationTransplantationKidney TransplantKidney Research +13

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Yi Luo, Laurie C. Warren, Donghui Xia, +6

Journal of Lipid Research

Octamer Formation and Coupling of Cardiac Sarcomeric Mitochondrial Creatine Kinase Are Mediated by Charged N-terminal Residues

Zaza Khuchua, Wenning Qin, Jaime Boero, +4

Journal of Biological Chemistry

Cardiac MuscleSignal TransductionMolecular PhysiologyBiochemistryMitochondrial Function +13

Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency

Daniel A. Skelly, Anne Czechanski, Candice Byers, +22

Cell stem cell

ChromatinChromatin StateChromatin RemodelingEpigenetic ChangeGenetics +8