Design and testing of a humanized porcine donor for xenotransplantation

R. Anand, Jacob V. Layer, Dávid Héja, +56

Nature

Extensive germline genome engineering in pigs

Yanan Yue, Weihong Xu, Yinan Kan, +39

Nature Biomedical Engineering

Developmental BiologyXenotransplantationEngineeringGeneticsSynthetic Biology +8

Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques

Dávid Ma, Takayuki Hirose, Grace Lassiter, +19

American Journal of Transplantation

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia

Shuo-Chieh Wu, Loretta S. Li, Nadja Kopp, +38

Cancer Cell

Hematological MalignancyMixed-phenotype Acute LeukemiaMalignant Blood DisorderImmunologyHematology +4

An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease

Andrew B. Munkacsi, Fannie W. Chen, Matthew Brinkman, +9

Journal of Biological Chemistry

HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma

Caron A. Jacobson, Nadja Kopp, Jacob V. Layer, +15

Blood

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Tovah A. Day, Jacob V. Layer, John P. Cleary, +11

Nature Communications

Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Jacob V. Layer, Lydie Debaize, Alexandria Van Scoyk, +9

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyMolecular GeneticsPolymerase δTranscriptional Regulation +16

Parp3 promotes long-range end joining in murine cells

Jacob V. Layer, John P. Cleary, Alexander J. Brown, +15

Proceedings of the National Academy of Sciences

Extensive Mammalian Germline Genome Engineering

Yanan Yue, Yinan Kan, Weihong Xu, +39

EngineeringTransgenic Mouse ModelsGeneticsImmunologyGermline Genetics +20