Edwin J. Matthews - Concepedia

Author

Edwin J. Matthews

United States Food and Drug Administration

Also Known As

E J Matthews, E MATTHEWS, E. J. Matthews, E.J. Matthews, Edwin J Matthews, Edwin J. Matthews, Edwin John Matthews, Edwin Matthews

Publications

1.9K

Citations

H-Index

Concepts

All Affiliations

United States Food and Drug Administration Center for Drug Evaluation and Research Center for Food Safety and Applied Nutrition Environmental Protection Agency LeadScope (United States)

About

Edwin J. Matthews is an author at United States Food and Drug Administration specializing in medicine, toxicology, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	21	26	1.5K
2	Public Health	7	7	469
3	Natural Sciences	3	3	64
4	Engineering	1	1	57
5	Health Sciences	1	1	17

Edwin J. Matthews

Publications

1.7K

Citations

H-Index

Page 1

	Year	Citations
A New Highly Specific Method for Predicting the Carcinogenic Potential of Pharmaceuticals in Rodents Using EnhancedMCASEQSAR-ES Software Edwin J. Matthews, Joseph F. Contrera Regulatory Toxicology and Pharmacology Predictive ToxicologyPreclinical Drug EvaluationMedicinePharmacologyPathology	1998	142
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints Edwin J. Matthews, Naomi L. Kruhlak, Michael C. Cimino, Regulatory Toxicology and Pharmacology Genetic ToxicityPredictive ToxicologyGeneticsDevelopmental ToxicologyGenetic Epidemiology	2005	132
Transformation of BALB/c-3T3 cells: V. Transformation responses of 168 chemicals compared with mutagenicity in Salmonella and carcinogenicity in rodent bioassays. Edwin J. Matthews, Judson W. Spalding, Raymond W. Tennant Environmental Health Perspectives Rodent BioassaysImmunologyToxicological MechanismBioanalysisToxicology	1993	97
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods Edwin J. Matthews, Naomi L. Kruhlak, Michael C. Cimino, Regulatory Toxicology and Pharmacology Predictive ToxicologyMedicinePathologyToxicologyToxicological Aspect	2005	96
Predicting the carcinogenic potential of pharmaceuticals in rodents using molecular structural similarity and E-state indices Joseph F. Contrera, Edwin J. Matthews, R. Benz Regulatory Toxicology and Pharmacology Tumor BiologyPredictive ToxicologyE-state IndicesMedicineRational Drug Design	2003	93
Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose Joseph F. Contrera, Edwin J. Matthews, Naomi L. Kruhlak, Regulatory Toxicology and Pharmacology Drug SafetyOncologyPharmacokinetic ModelingQsar ModelingObserved Effect Level	2004	88
Assessment of the Health Effects of Chemicals in Humans: I. QSAR Estimation of the Maximum Recommended Therapeutic Dose (MRTD) and No Effect Level (NOEL) of Organic Chemicals Based on Clinical Trial Data1 Edwin J. Matthews, Naomi L. Kruhlak, R. Benz, Current Drug Discovery Technologies Animal Toxicology StudiesExposure AssessmentMedicinal ChemistryI. Qsar EstimationToxicology	2004	84
Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action–Based Predictions of Chemical Carcinogenesis in Rodents Edwin J. Matthews, Naomi L. Kruhlak, R. Benz, Toxicology Mechanisms and Methods Systems PharmacologyQsar ProgramsOncologyChemical CarcinogenesisToxicology	2008	78
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities Edwin J. Matthews, Carling Ursem, Naomi L. Kruhlak, Regulatory Toxicology and Pharmacology Drug SafetyMedicineDrug DiscoveryForensic ToxicologySar Systems	2009	77
Prediction of drug-related cardiac adverse effects in humans-B: Use of QSAR programs for early detection of drug-induced cardiac toxicities Anna A. Frid, Edwin J. Matthews Regulatory Toxicology and Pharmacology Drug SafetyQsar ProgramsHeart FailurePredictive ToxicologyCardiovascular Disease	2009	71

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