A New Highly Specific Method for Predicting the Carcinogenic Potential of Pharmaceuticals in Rodents Using EnhancedMCASEQSAR-ES Software

Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

John Ashby, Raymond W. Tennant · Mutation Research/Reviews in Genetic Toxicology · 1991 · 685 citations

Pharmacy, Chemistry, Toxicology +15

Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules

Gilles Klopman · Journal of the American Chemical Society · 1984 · 428 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Describing the validity of carcinogen screening tests

Jeremy Cooper, Rodolfo Saracci, Philip Cole · British Journal of Cancer · 1979 · 350 citations

Medicine, Oncology, Toxicology +12

MULTICASE 1. A Hierarchical Computer Automated Structure Evaluation Program

Gilles Klopman · Quantitative Structure-Activity Relationships · 1992 · 314 citations

Pharmacy, Medicinal Chemistry, Computational Chemistry +12

Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program

Raymond W. Tennant, John Ashby · Mutation Research/Reviews in Genetic Toxicology · 1991 · 227 citations

Pharmacy, Toxicology, Environmental Toxicology +8