Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

Christopher R. Coxon, Elizabeth Anscombe, Suzannah J. Harnor, +18

Journal of Medicinal Chemistry

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Gianni Chessari, Ian R. Hardcastle, Jong Sook Ahn, +39

Journal of Medicinal Chemistry

Trifluoroacetic Acid in 2,2,2‐Trifluoroethanol Facilitates S_NAr Reactions of Heterocycles with Arylamines

Benoît Carbain, Christopher R. Coxon, Honorine Lebraud, +10

Chemistry - A European Journal

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

Michaela Hylsová, Benoît Carbain, Jindřich Fanfrlík, +11

European Journal of Medicinal Chemistry

Deep Eutectic SolventSolvent ScoringChemical AnalysisExplicit TreatmentChemistry +3

Efficient Synthesis of Highly Active Phospha‐Isosteres of the Influenza Neuraminidase Inhibitor Oseltamivir

Benoît Carbain, Patrick Collins, Lori Callum, +4

ChemMedChem

Bioorganic ChemistrySynthetic VirologyEfficient SynthesisChemistryAntiviral Drug +14

Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles

Honorine Lebraud, Christopher R. Coxon, Victoria S. Archard, +10

Organic & Biomolecular Chemistry

Preparation of 3,4-Substituted-5-Aminopyrazoles and 4-Substituted-2-Aminothiazoles

Štěpán Havel, Prashant Khirsariya, Naresh Akavaram, +2

The Journal of Organic Chemistry

Medicinal ChemistryDiversity Oriented SynthesisDerivativesDerivative (Chemistry)Suzuki Coupling +12

8-Substituted <i>O</i>⁶-Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode

Benoît Carbain, David J. Paterson, Elizabeth Anscombe, +13

Journal of Medicinal Chemistry

Drug TargetPurine C-8 SubstitutionPharmacotherapyChemical BiologyReversed Binding Mode +18

Galactose-conjugates of the oseltamivir pharmacophore—new tools for the characterization of influenza virus neuraminidases

Benoît Carbain, Stephen R. Martin, Patrick Collins, +2

Organic & Biomolecular Chemistry

‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

Mathew Stanley, Nicholas Cattle, John W. McCauley, +5

MedChemComm

NanoparticlesNanotherapeuticsEngineeringImmunology‘ Tamigold ’ +14