Radu Vasilcanu

β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase

Leonard Girnita, Sudha K. Shenoy, Bita Sehat et al. · Journal of Biological Chemistry · 2005 · 164 citations · Full text

Molecular Regulation, Immunology, Insulin Signaling +16

The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway

Daiana Vasilcanu, Ada Girnita, Leonard Girnita et al. · Oncogene · 2004 · 151 citations

Tyrosine Phosphorylation, Insulin Signaling, Signal Transduction +12

β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression

Leonard Girnita, Sudha K. Shenoy, Bita Sehat et al. · Journal of Biological Chemistry · 2007 · 133 citations · Full text

Signal Transduction, Cell Cycle Progression, Proteasome-dependent Destruction +14

Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation

Bita Sehat, Sandra Andersson, Radu Vasilcanu et al. · PLoS ONE · 2007 · 79 citations · Full text

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and β-arrestin1

Radu Vasilcanu, D. Vasilcanu, Lars Rosengren et al. · Oncogene · 2007 · 73 citations

Molecular Pharmacology, Potential Mechanistic Involvement, Molecular Physiology +10