SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

Bita Sehat, Ali Asghar Tofigh, Yingbo Lin, +4

Science Signaling

β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase

Leonard Girnita, Sudha K. Shenoy, Bita Sehat, +4

Journal of Biological Chemistry

Molecular RegulationImmunologyInsulin SignalingMdm2 E3 LigaseSignaling Pathway +14

β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression

Leonard Girnita, Sudha K. Shenoy, Bita Sehat, +5

Journal of Biological Chemistry

Signal TransductionCell Cycle ProgressionProteasome-dependent DestructionCell RegulationReceptor Tyrosine Kinase +12

Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis

Bita Sehat, Sandra Andersson, Leonard Girnita, +1

Cancer Research

Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling

Nina Rawal, Olga Corti, Paola Sacchetti, +4

Biochemical and Biophysical Research Communications

Molecular NeuroscienceSynaptic SignalingDopaminergic NeuronsNeuroscienceMolecular Neurobiology +5

Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF

Dudi Warsito, Sylvia Sjöström, Sandra Andersson, +2

EMBO Reports

Transcriptional RegulationNuclear Igf1rMedicineCell BiologyGene Expression +2

Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation

Bita Sehat, Sandra Andersson, Radu Vasilcanu, +2

PLoS ONE

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and β-arrestin1

Radu Vasilcanu, D. Vasilcanu, Lars Rosengren, +7

Oncogene

Molecular PharmacologyPotential Mechanistic InvolvementMolecular PhysiologySignal TransductionBiochemistry +8

Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9

Hua Deng, Yingbo Lin, Margherita Badin, +5

Biochemical and Biophysical Research Communications

Signal TransductionSignaling PathwayElevated ExpressionCell RegulationMedicine +8

Nuclear translocation of IGF-1R via p150Glued and an importin-β/RanBP2-dependent pathway in cancer cells

Sylvia Packham, Dudi Warsito, Yingbo Lin, +4

Oncogene

Cancer ResearchImportin-β/ranbp2-dependent PathwayMedicineCancer Cell BiologyFibroblast Growth Factor +8