Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

Susumu Goyama, Go Yamamoto, Munetake Shimabe, +5

Cell stem cell

MedicineStem Cell MobilizationImmunologyHematologyCritical Regulator +8

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

Keisuke Kataoka, Tomohiko Sato, Akihide Yoshimi, +12

The Journal of Experimental Medicine

Adult Bone MarrowCell LineageDevelopmental BiologyHealth SciencesMedicine +12

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

Akihide Yoshimi, Susumu Goyama, Naoko Watanabe‐Okochi, +10

Blood

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells

Shunya Arai, Akihide Yoshimi, Munetake Shimabe, +5

Blood

EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization

Susumu Goyama, Eriko Nitta, Toshihiko Yoshino, +6

Leukemia

Histone ModificationsChromatinTranscriptional RegulationHistone Methyltransferases Suv39h1Chromatin Remodeling +10

Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

Munetake Shimabe, Susumu Goyama, Naoko Watanabe‐Okochi, +4

Oncogene

Hematological MalignancyHematopoietic Stem/progenitorsLeukemic CellsMedicineMixed-phenotype Acute Leukemia +10

Safety, tolerability and efficacy of repeated intravenous infusions of KHK4083, a fully human anti-OX40 monoclonal antibody, in Japanese patients with moderate to severe atopic dermatitis

Hidemi Nakagawa, Hajime Iizuka, Osamu Nemoto, +4

Journal of Dermatological Science

AllergyAtopic DermatitisAllergy MedicineMedicineImmunology +7

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors

Masahiro Nakagawa, Munetake Shimabe, Naoko Watanabe‐Okochi, +11

Blood

Changes in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries

Kouji Komatsu, Noboru MANABE, Minako Kiso, +2

Journal of Experimental Zoology Part A Comparative Experimental Biology

Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries

Kouji Komatsu, Noboru MANABE, Minako Kiso, +2

Molecular Reproduction and Development