Cor Breukel

Mutations in the APC tumour suppressor gene cause chromosomal instability

Riccardo Fodde, Jeroen Kuipers, Carla Rosenberg et al. · Nature Cell Biology · 2001 · 717 citations

Genome Instability, Somatic Variant, Genetics +7

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

Riccardo Fodde, Winfried Edelmann, Kan Yang et al. · Proceedings of the National Academy of Sciences · 1994 · 526 citations · Full text

Large Bowel, Targeted Chain-termination Mutation, Gastroenterology +16

Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

Menno F. Kielman, Maaret Rindapää, Cláudia Gaspar et al. · Nature Genetics · 2002 · 351 citations

Stem Cell Biology, Developmental Biology, β-Catenin Signaling +10

APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression

Klaus‐Peter Janssen, Paola Alberici, Hafida Fsihi et al. · Gastroenterology · 2006 · 281 citations · Full text

Signal Transduction, Signaling Pathway, Gastrointestinal Oncology +10

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

Ron Smits, Menno F. Kielman, Cor Breukel et al. · Genes & Development · 1999 · 235 citations · Full text