Mutations in the APC tumour suppressor gene cause chromosomal instability

Riccardo Fodde, Jeroen Kuipers, Carla Rosenberg, +8

Nature Cell Biology

Genome InstabilitySomatic VariantGeneticsMolecular GeneticsChromosomal Rearrangement +5

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

Riccardo Fodde, Winfried Edelmann, Kan Yang, +7

Proceedings of the National Academy of Sciences

Large BowelTargeted Chain-termination MutationGastroenterologyPathologyMultiple Intestinal Tumors +14

Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

Menno F. Kielman, Maaret Rindapää, Cláudia Gaspar, +7

Nature Genetics

Stem Cell BiologyDevelopmental Biologyβ-Catenin SignalingMedicineStem Cell Research +8

APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression

Klaus‐Peter Janssen, Paola Alberici, Hafida Fsihi, +10

Gastroenterology

Signal TransductionSignaling PathwayGastrointestinal OncologyMedicineIntestinal Tumor Formation +8

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

Ron Smits, Menno F. Kielman, Cor Breukel, +10

Genes & Development

Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer in the United States: High Mutation Detection Rate among Clinically Selected Families and Characterization of an American Founder Genomic Deletion of the MSH2 Gene

Anja Wagner, Alicia Barrows, Juul Wijnen, +19

The American Journal of Human Genetics

OncologySomatic VariantMedicineGeneticsMolecular Analysis +9

Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.

Diana Eccles, Rob B. van der Luijt, Cor Breukel, +8

PubMed

Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli

Rob B. van der Luijt, P. Meera Khan, Hans F. A. Vasen, +4

Human Genetics

MedicineGeneticsNatural SciencesProtein GeneticsMolecular Biology +6

Apc1638N: A mouse model for familial adenomatous polyposis–associated desmoid tumors and cutaneous cysts

Ron Smits, Willemien van der Houven van Oordt, Arne Luz, +5

Gastroenterology

Tumor BiologyTumoral PathologyCutaneous CystsDesmoid TumorsMedicine +7

APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis

Rob B. van der Luijt, Hans F. A. Vasen, Carli M.J. Tops, +3

Human Genetics

Apc MutationSpliced RegionMendelian DisorderGenetic DisorderFamilial Adenomatous Polyposis +7