Akiko Osada

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

Nozomu Tanaka, Kazuki Sakamoto, Hiroyuki Okabe et al. · Oncology Reports · 2014 · 142 citations · Full text

Medicine, Oncology, Pharmacology +13

Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNA

Kazuki Sakamoto, Tatsushi Yokogawa, Hiroyuki Ueno et al. · International Journal of Oncology · 2015 · 57 citations · Full text

Medicine, Oncology, Pharmacology +13

dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Tatsushi Yokogawa, Wakako Yano, Sayaka Tsukioka et al. · Cancer Science · 2020 · 41 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

<scp>TAS2940</scp>, a novel <scp>brain‐penetrable pan‐ERBB</scp> inhibitor, for tumors with <i>HER2</i> and <i>EGFR</i> aberrations

Kei Oguchi, Hikari Araki, Shingo Tsuji et al. · Cancer Science · 2022 · 13 citations · Full text

Medicine, Oncology, Pharmacology +16

Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as check point 1 kinase inhibitors

Yuki Sako, Satoshi Ichikawa, Akiko Osada et al. · Bioorganic & Medicinal Chemistry · 2010 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12