Nuclear Spin−Spin Coupling via Nonbonded Interactions. 8.¹ The Distance Dependence of Through-Space Fluorine−Fluorine Coupling

Frank B. Mallory, Clelia W. Mallory, Kelly E. Butler, +13

Journal of the American Chemical Society

Nuclear PhysicsNmr SpectroscopySpin SystemsMagnetic ResonanceComputational Chemistry +15

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Jianguo Li, Jin Chiu, Mercy Ramanjulu, +2

Molecular Neurodegeneration

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

William Fried, Mrityunjay Tyagi, Leonid Minakhin, +20

Nature Communications

The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

Christopher Hulme, K.J.M. Moriarty, Bruce E. Miller, +10

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryNovel SeriesBiochemistryNatural Sciences +8

Synthesis and evaluation of succinoyl-caprolactam γ-secretase inhibitors

Lorin A. Thompson, Ann Y. Liauw, Mercy Ramanjulu, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceSuccinoyl-caprolactam γ-Secretase InhibitorsMedicine +6

MC-100093, a Novel β-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats

Lori A. Knackstedt, Lizhen Wu, Jeffrey Rothstein, +7

Journal of Pharmacology and Experimental Therapeutics

Orally active indole N-oxide PDE4 inhibitors

Christopher Hulme, Rose Mathew, K.J.M. Moriarty, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyPharmacology +3

Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors

Michael G. Yang, Jianliang Shi, Dilip P. Modi, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPotent γ-Secretase InhibitorsPharmaceutical ScienceBiochemistryNatural Sciences +7

Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome

Benjamin E. Blass, Pravin S. Iyer, Magid Abou‐Gharbia, +16

Bioorganic & Medicinal Chemistry Letters

Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17)

Benjamin E. Blass, Pravin S. Iyer, Magid Abou‐Gharbia, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineOrganic Chemistry +4