The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

Jixi Li, Thomas J. McQuade, Ansgar B. Siemer, +9

Cell

InflammationAlzheimer's DiseaseCell DeathPathologyDegenerative Pathology +7

Widespread and Functional RNA Circularization in Localized Prostate Cancer

Sujun Chen, Vincent Huang, Xin Xu, +46

Cell

Functional Rna CircularizationProstatic DiseaseSystems BiologyMedicineTumor Biology +1

Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection

Bei Wang, Rui Wang, Daqi Wang, +5

Analytical Chemistry

Aerosol ContaminationEngineeringMolecular BiologyNucleic Acid Amplification TestNucleic Acid Detection +15

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Miguel Mompeán, Wenbo Li, Jixi Li, +5

Cell

Necrosome Ripk1-ripk3 CoreProtein FunctionNatural SciencesMolecular BiologyDegenerative Pathology +5

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Siyun Kuang, Jun Zheng, Hui Yang, +7

Proceedings of the National Academy of Sciences

Crystal structure of an RNA-cleaving DNAzyme

Hehua Liu, Yu Xiang, Yiqing Chen, +12

Nature Communications

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Zhen Wei, Jinglue Song, Guanghui Wang, +8

Nature Communications

Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling

Anni Kleino, Nancy Ramia, Günes Bozkurt, +9

Immunity

Protein FunctionMolecular PhysiologySignal TransductionFunctional AmyloidsNatural Sciences +10

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Wenqing Gao, Yuanyuan Li, Xuehe Liu, +17

Cell Death and Differentiation

Transcriptional RegulationCell RegulationMolecular RegulationNatural SciencesApoptosis +7

E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis

Pucheng Mei, Feiyan Xie, Jiasong Pan, +10

Cell Death and Differentiation