Christoph W. Grathwol

Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs

Qingyun Tang, Christoph W. Grathwol, Aşkın S. Aslan‐Üzel et al. · Angewandte Chemie International Edition · 2020 · 115 citations · Full text

Engineering, Biochemistry, Biotechnology +14

Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β‐Hydroxylation of Lithocholic Acid

Sascha Grobe, Christoffel P. S. Badenhorst, Thomas Bayer et al. · Angewandte Chemie International Edition · 2020 · 74 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Influence of Substrate Binding Residues on the Substrate Scope and Regioselectivity of a Plant <i>O</i>‐Methyltransferase against Flavonoids

Qingyun Tang, Yoanes Maria Vianney, Klaus Weisz et al. · ChemCatChem · 2020 · 18 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +14

Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation

R. Hofstetter, Mahmoud Hasan, Georg M. Fassauer et al. · Journal of Chromatography A · 2019 · 16 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +12

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

Christoph W. Grathwol, Nathalie Wössner, Sören Swyter et al. · Beilstein Journal of Organic Chemistry · 2019 · 15 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15