Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara, +12

Proceedings of the National Academy of Sciences

Tumor BiologyOncologyAmino Acid ResponseChemoprevention StrategyOncogenic Agent +12

Proteomic identification of differentially‐expressed genes in human gastric carcinomas

Ryuichi Nishigaki, Mitsuhiko Osaki, Masaharu Hiratsuka, +6

PROTEOMICS

Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

Candice Tahimic, Nozomi Tomimatsu, Ryuichi Nishigaki, +6

Biochemical and Biophysical Research Communications

Developmental BiologySignal TransductionSignaling PathwayNon-neuronal CellsCell Interaction +7

Searching for Genes Involved in Arteriosclerosis: Proteomic Analysis of Cultured Human Umbilical Vein Endothelial Cells Undergoing Replicative Senescence

Hiroki Kamino, Masaharu Hiratsuka, Tosifusa Toda, +5

Cell Structure and Function

Replicative SenescenceAngiogenesisGenes InvolvedProteomicsAtherosclerosis +14

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents

Keisuke Imamura, Naoki Tomita, Youichi Kawakita, +15

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +7

Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21

Chi Chiu Wang, Mitsutaka Kadota, Ryuichi Nishigaki, +6

Biochemical and Biophysical Research Communications

ChromatinCell LineageMolecular NeuroscienceMouse Es CellsGenetics +9

Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: An in vitro model of down syndrome

Mitsutaka Kadota, Ryuichi Nishigaki, Chi Chiu Wang, +7

Neuroscience

Down SyndromeEmbryonic Stem CellCell LineageDevelopmental BiologyCell Specialization +11

Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice

Yasuhiro Kazuki, Motoshi I. Kimura, Ryuichi Nishigaki, +9

Biochemical and Biophysical Research Communications

Genetic DisorderGeneticsMolecular GeneticsEpigeneticsDisease Gene Identification +6

An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome

Ryuichi Nishigaki, Tokuyuki Shinohara, Tosifusa Toda, +6

Biochemical and Biophysical Research Communications

Down SyndromeChromatinCytogeneticsGenetic DisorderGenetics +6