Sundeep Khosla

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.2K citations

Education, Geriatric Medicine, Physiology +14

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson, Larissa Prata, Shane A. Bobart et al. · EBioMedicine · 2019 · 1.3K citations · Full text

Veterinary Medicine, Pharmacology, Pharmacotherapy +17

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr, Ming Xu, Megan Weivoda et al. · Nature Medicine · 2017 · 1.1K citations · Full text

Medicine, Geriatric Medicine, Aging +9

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson et al. · Nature Communications · 2022 · 969 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12