Andrew K. Kwegyir‐Afful

Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer

Puranik Purushottamachar, Abhijit M. Godbole, Lalji K. Gediya et al. · Journal of Medicinal Chemistry · 2013 · 103 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts<i>in vivo</i>

Andrew K. Kwegyir‐Afful, Senthilmurugan Ramalingam, Puranik Purushottamachar et al. · Oncotarget · 2015 · 99 citations · Full text

Medicine, Oncology, Pharmacology +17

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines

Senthilmurugan Ramalingam, Lalji K. Gediya, Andrew K. Kwegyir‐Afful et al. · Oncotarget · 2014 · 56 citations · Full text

Life Sciences, Oncology, Pharmacology +15

Galeterone and <scp>VNPT</scp>55 disrupt Mnk‐<scp>eIF</scp>4E to inhibit prostate cancer cell migration and invasion

Andrew K. Kwegyir‐Afful, Robert D. Bruno, Puranik Purushottamachar et al. · FEBS Journal · 2016 · 49 citations · Full text

Medicine, Oncology, Pharmacology +17

Novel C-4 Heteroaryl 13-<i>cis</i>-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice

Hannah W. Mbatia, Senthilmurugan Ramalingam, Vidya P. Ramamurthy et al. · Journal of Medicinal Chemistry · 2015 · 31 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14