Puranik Purushottamachar

Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer

Puranik Purushottamachar, Abhijit M. Godbole, Lalji K. Gediya et al. · Journal of Medicinal Chemistry · 2013 · 103 citations · Full text

Androgen Receptor, Pharmacotherapy, Chemical Biology +22

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts<i>in vivo</i>

Andrew K. Kwegyir‐Afful, Senthilmurugan Ramalingam, Puranik Purushottamachar et al. · Oncotarget · 2015 · 99 citations · Full text

A New Simple and High-Yield Synthesis of Suberoylanilide Hydroxamic Acid and Its Inhibitory Effect Alone or in Combination with Retinoids on Proliferation of Human Prostate Cancer Cells

Lalji K. Gediya, Pankaj Chopra, Puranik Purushottamachar et al. · Journal of Medicinal Chemistry · 2005 · 98 citations

Competitive Antagonism between the Nicotinic Allosteric Potentiating Ligand Galantamine and Kynurenic Acid at α7* Nicotinic Receptors

Cristiane Lopes, Edna F. R. Pereira, Hui‐Qiu Wu et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 78 citations

Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model

Robert D. Bruno, Tadas S. Vasaitis, Lalji K. Gediya et al. · Steroids · 2011 · 76 citations · Full text

Stable Analogs, Biological Evaluations, Medicine +9