William Lennox

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Liangxian Cao, Marla Weetall, Christopher R. Trotta et al. · Molecular Cancer Therapeutics · 2018 · 85 citations

Medicine, Oncology, Pharmacology +14

Structure–Activity Relationship (SAR) Optimization of 6-(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B

Nanjing Zhang, Xiaoyan Zhang, Jin Zhu et al. · Journal of Medicinal Chemistry · 2013 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes

Kensuke Kayamori, Yurie Nagai, Cheng Zhong et al. · Blood Advances · 2021 · 36 citations · Full text

Medicine, Oncology, Pharmacology +16

Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B

Xiaoyan Zhang, Nanjing Zhang, Guangming Chen et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 35 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform

Liangxian Cao, Marla Weetall, J. Bombard et al. · PLoS ONE · 2016 · 21 citations · Full text

Medicine, Medicinal Chemistry, Oncology +16