William H. Gittens

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

Nícolas C. Hoch, Hana Hanzlíková, Stuart L. Rulten et al. · Nature · 2016 · 263 citations · Full text

Xrcc1 Mutation, Molecular Neuroscience, Genetic Disorder +6

Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin

Hana Hanzlíková, William H. Gittens, Kateřina Krejčíková et al. · Nucleic Acids Research · 2016 · 198 citations · Full text

Endogenous Xrcc1, Chromatin, Genome Instability +14

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

Annie Albert Demin, Kouji Hirota, Masataka Tsuda et al. · Molecular Cell · 2021 · 188 citations · Full text

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

William H. Gittens, Dominic Johnson, Rachal M. Allison et al. · Nature Communications · 2019 · 101 citations · Full text

The Tomato Nucleotide-binding Leucine-rich Repeat Immune Receptor I-2 Couples DNA-binding to Nucleotide-binding Domain Nucleotide Exchange

Stepan Fenyk, Christopher H. Dixon, William H. Gittens et al. · Journal of Biological Chemistry · 2015 · 23 citations · Full text