Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor

Jason R. Schmink, Chad M. Kormos, William G. Devine, +1

Organic Process Research & Development

Chemical EngineeringMicrowave SynthesisEngineeringChemical TransformationReaction Engineering +9

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Jennifer Chu, Wenhan Zhang, Regina Cencic, +7

Cell chemical biology

Medicinal ChemistryDrug TargetMedicinePharmacotherapyDrug Development +3

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Jennifer Chu, Wenhan Zhang, Regina Cencic, +10

Cell Reports

Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery

William G. Devine, Jennifer L. Woodring, Uma Swaminathan, +10

Journal of Medicinal Chemistry

Antiparasitic AgentMalariaImmunologyPathologyLead Identification +18

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

Salomon Manier, Daisy Huynh, Yu J. Shen, +19

Science Translational Medicine

Viscosity B-coefficients at 15 and 25 °C for glycine, β-alanine, 4-amino-n-butyric acid, and 6-amino-n-hexanoic acid in aqueous solution

William G. Devine, B. M. Lowe

Journal of the Chemical Society A Inorganic Physical Theoretical

Food ChemistryEngineeringMolecular ThermodynamicsAqueous SolutionSolvent Structure Breakers +13

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

Emanuele Amata, Joel W. Beatty, Zeke T. Clements, +10

Journal of Medicinal Chemistry

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign

Rosario Díaz-González, Sandra A. Luengo-Arratta, João Seixas, +15

PLoS neglected tropical diseases

Drug TargetAntiparasitic AgentImmunologyMolecular BiologyPathology +14

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas

Xuan Zhang, Chengfeng Bi, Ting Lu, +13

Leukemia

Lymphoid NeoplasiaNovel TherapyClinical TranslationMedicineSynthetic Rocaglates +9

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites

William G. Devine, Sarah M. Thomas, Jessey Erath, +7

ACS Medicinal Chemistry Letters