Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Manuel Hayn, Maximilian Hirschenberger, Lennart Koepke, +21

Cell Reports

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Elisabeth Braun, Dominik Hotter, Lennart Koepke, +18

Cell Reports

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volčič, +29

Nature Communications

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Lukas Wettstein, Tatjana Weil, Carina Conzelmann, +27

Nature Communications

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

Chiara Pastorio, Fabian Zech, Sabrina Noettger, +5

Cell Host & Microbe

Immune EvasionViral EvolutionSpike ProteinOmicron Spike ProteinVaccine Target +10

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Fabian Zech, Daniel Schniertshauer, Christoph Jung, +19

Nature Communications

SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells

Rayhane Nchioua, Annika Schundner, Dorota Kmieć, +9

Journal of Virology

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

Rayhane Nchioua, Annika Schundner, Susanne Klute, +14

Life Science Alliance

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

Lukas Wettstein, Carina Conzelmann, Janis A. Müller, +22

Suppress Sars-cov-2Lung InflammationRespiratory DiseasesViral Spike ProteinViral Pathogenesis +10

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volčič, +27

InflammationVirus InhibitionSars-cov-2 InfectionIfitm-derived PeptidesIfitms 1 +10