The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism

Xukun Deng, Wu Yin, Weidong Li, +5

Journal of Ethnopharmacology

Strychnos Nux-vomicaMedicineHepg2 CellsPhytopharmacologyAnti-cancer Agent +6

Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice

Lvyi Chen, Zhou Lan, Qinxiong Lin, +6

Food and Chemical Toxicology

InflammationGlomerulonephritisUrologyRenal FunctionMedicine +10

Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells <i>in Vitro</i> and <i>in Vivo</i>

Wei Li, Ji Hao, Lang Zhang, +3

Journal of Agricultural and Food Chemistry

Chemoprevention StrategyPathologyGlucose GlycolysisHcc Tumor GrowthCancer Biology +18

The Apoptotic Effect of Brucine from the Seed of Strychnos nux-vomica on Human Hepatoma Cells is Mediated via Bcl-2 and Ca2+ Involved Mitochondrial Pathway

Xukun Deng, Fangzhou Yin, Xiaoyu Lu, +2

Toxicological Sciences

Chemoprevention StrategyApoptosisImmunologyCell DeathRedox Biology +18

Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation

Wei Li, Yunhan Qiu, Ji Hao, +3

Food and Chemical Toxicology

Tumor BiologyOncologyHk2/pkm2 ModulationMedicineLiver Physiology +9

The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells

Wu Yin, Xukun Deng, Fangzhou Yin, +2

Food and Chemical Toxicology

Smmc 7221MedicineLipid PeroxidationApoptosisCell Death +7

Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl₄: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis

Guangwen Shu, Arslan Yusuf, Chenxi Dai, +2

Food & Function

γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways

Guangwen Shu, Yunhan Qiu, Ji Hao, +2

Food & Function

Apap ToxicityImmunologyCell DeathRedox BiologyOxidative Stress +14

A flavonoid component from Docynia delavayi (Franch.) Schneid represses transplanted H22 hepatoma growth and exhibits low toxic effect on tumor-bearing mice

Xiangpei Zhao, Guangwen Shu, Lvyi Chen, +3

Food and Chemical Toxicology

Docynia DelavayiMedicineLiver PhysiologyHerb-drug InteractionPathology +8

Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade

Guangwen Shu, Yunhan Qiu, Ji Hao, +2

Journal of Functional Foods

InflammationHepatologyMedicineLiver PhysiologyImmunology +10