Alvin Chan

Neuroblastoma is composed of two super-enhancer-associated differentiation states

Tim van Groningen, Jan Köster, Linda J. Valentijn et al. · Nature Genetics · 2017 · 571 citations · Full text

Life Sciences, Cancer Biology, Developmental Biology +11

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout et al. · Nature Communications · 2019 · 172 citations · Full text

Medicine, Cell Biology, Oncology +16

The Phox2B homeobox gene is mutated in sporadic neuroblastomas

Vera van Limpt, Alexander Schramm, Arjan Lakeman et al. · Oncogene · 2004 · 139 citations

Medicine, Genetics, Molecular Genetics +8

Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.

N C Cheng, Nadine Van Roy, Alvin Chan et al. · PubMed · 1995 · 112 citations

Medicine, Genetics, Molecular Genetics +14

The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta–Notch pathway in neuroblastoma

Ingrid Revet, Gerda Huizenga, Alvin Chan et al. · Experimental Cell Research · 2007 · 74 citations

Life Sciences, Cell Biology, Molecular Genetics +14