Seiya Tokunaga

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

Shuo‐Chien Ling, Claudio P. Albuquerque, Joo Seok Han et al. · Proceedings of the National Academy of Sciences · 2010 · 453 citations · Full text

Neurodegenerative Diseases, Tdp-43 Increase, Protein Function +14

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

Shuying Sun, Shuo‐Chien Ling, Jinsong Qiu et al. · Nature Communications · 2015 · 233 citations · Full text

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

Shuying Sun, Ying Sun, Shuo‐Chien Ling et al. · Proceedings of the National Academy of Sciences · 2015 · 196 citations · Full text

Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy

Constanza J. Cortés, Shuo‐Chien Ling, Ling Guo et al. · Neuron · 2014 · 175 citations · Full text

Muscle Expression, Neurodegenerative Diseases, Skeletal Muscle +10

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

Shuo‐Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga et al. · eLife · 2019 · 87 citations · Full text

Mitophagy, Genetics, Cell Death +21