Cahir J. O’Kane

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations · Full text

Cell Autophagy, Mitophagy, Medicine +9

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

Sean T. Sweeney, Kendal Broadie, John Keane et al. · Neuron · 1995 · 972 citations · Full text

Biology, Synaptic Plasticity, Signal Transduction +7

Lysosomal positioning coordinates cellular nutrient responses

Viktor I. Korolchuk, Shinji Saiki, Maike Lichtenberg et al. · Nature Cell Biology · 2011 · 876 citations · Full text

Biology, Cell Division, Cell Organelle +6

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

Ashley R. Winslow, Chien‐Wen Chen, Silvia Corrochano et al. · The Journal of Cell Biology · 2010 · 808 citations · Full text

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

Andrea Williams, Sovan Sarkar, Paul A. Cuddon et al. · Nature Chemical Biology · 2008 · 779 citations · Full text

Cell Autophagy, Mitophagy, Mtor-independent Autophagy Pathway +7