Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Frauke Christ, Arnout Voet, Arnaud Marchand, +10

Nature Chemical Biology

Rational DesignLedgf/p75-integrase InteractionMedicineNatural SciencesAntiviral Drug Development +9

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Suzanne J. F. Kaptein, Olivia Goethals, Dominik Kiemel, +21

Nature

Ns3–ns4b InteractionImmunologyAntiviral Drug DevelopmentVirologyAntiviral Drug +2

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor <i>In Vitro</i> and Confer Resistance To Nirmatrelvir

Dirk Jochmans, Kim Donckers, Antitsa Stoycheva, +21

mBio

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Olivia Goethals, Suzanne J. F. Kaptein, Bart Kesteleyn, +41

Nature

Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors

Dorothée Bardiot, Mohamed Koukni, Wim Smets, +7

Journal of Medicinal Chemistry

Denv Serotype 23-Acyl-indole Derivative 1BiochemistryIndole DerivativesMedicine +10

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

Cheng Liu, Sandro Boland, Michael D. Scholle, +10

Antiviral Research

Rhinovirus Hrv3c ProteaseImmunologyAntiviral DrugViral Structural ProteinCovid-19 +16

The substitutions L50F, E166A and L167F in SARS-CoV-2 3CLpro are selected by a protease inhibitor <i>in vitro</i> and confer resistance to nirmatrelvir

Dirk Jochmans, Kim Donckers, Antitsa Stoycheva, +21

2′-<i>C</i>-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

S. Benzaria, Dorothée Bardiot, Tony Bouisset, +21

Antiviral chemistry & chemotherapy

Viral ReplicationBioorganic ChemistryViral Polymerase StructureViral Polymerase MechanismMolecular Biology +15

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

Koen Vandyck, Rana Abdelnabi, Kusum Gupta, +20

Biochemical and Biophysical Research Communications

MedicineImmunologyAntiviral Drug DevelopmentTherapeutic EfficacyVivo Efficacy +4

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor

Bart Kesteleyn, Jean‐François Bonfanti, Dorothée Bardiot, +18

Journal of Medicinal Chemistry