Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

Kathrin Renner, Annette Schnell, Gudrun E. Koehl, +38

Cell Reports

Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation

Hila Schwartz, Eran Blacher, Malak Amer, +15

Cancer Research

ImmunologyBiological MicroenvironmentsMalignant MelanomaBrain LesionMelanoma Cells +17

The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study

Laila Siam, Annalen Bleckmann, Han-Ning Chaung, +9

Oncotarget

PI3K: A master regulator of brain metastasis‐promoting macrophages/microglia

Raquel Blazquez, Darius Wlochowitz, Alexander Wolff, +23

Glia

Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis

Hila Doron, Malak Amer, Nour Ershaid, +17

Cell Reports

ImmunologyGliomaMelanoma CellsNeuroinflammationInflammation +16

Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2

Omer Adler, Yael Zait, Noam Cohen, +18

Nature Cancer

InflammationNeuro-oncologyGliomaReciprocal InteractionsMedicine +10

LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer

Raquel Blazquez, Eva Rietkötter, Britta Wenske, +32

International Journal of Cancer

Tumor BiologyGlutathione MetabolismMetastatic Brain ColonizationGliomaMedicine +13

Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment

Florian Lüke, Raquel Blazquez, Rezan Fahrioglu Yamaci, +19

Oncotarget

Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain

Raquel Blazquez, Han‐Ning Chuang, Britta Wenske, +14

Oncogene

3D Coculture Model of the Brain Parenchyma–Metastasis Interface of Brain Metastasis

Raquel Blazquez, Tobias Pukrop

Methods in molecular biology

Tumor InnervationBrain Parenchyma–metastasis InterfaceCoculture ModelBrain MetastasisCancer Cell Biology +6