Helen R. Josephine - Concepedia

Author

Helen R. Josephine

Wesleyan University

Also Known As

H.R. Josephine, Helen R Josephine, Helen R. Josephine

Publications

468

Citations

H-Index

Concepts

All Affiliations

Wesleyan University Brandeis University University of Liège Medical University of South Carolina Forma Therapeutics (United States)

About

Helen R. Josephine is an author at Wesleyan University specializing in natural sciences, biochemistry, and molecular biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	5	5	188
2	Biochemistry	5	5	188
3	Engineering	1	1	22
4	Medicine	1	1	43
5	Microbiology	1	1	43

Helen R. Josephine

Publications

447

Citations

H-Index

Page 1

	Year	Citations
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor Justin A. Caravella, Jian Lin, R. Bruce Diebold, Journal of Medicinal Chemistry	2020	132
Crystal Structures of Complexes between the R61 DD-peptidase and Peptidoglycan-mimetic β-Lactams: A Non-covalent Complex with a “Perfect Penicillin” N.R. Silvaggi, Helen R. Josephine, A.P. Kuzin, Journal of Molecular Biology Peptidoglycan-mimetic β-LactamsBiochemistryNatural SciencesProtein X-ray CrystallographyMolecular Biology	2004	58
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors Jian Lin, Wei Lu, Justin A. Caravella, Journal of Medicinal Chemistry	2019	46
The Perfect Penicillin? Inhibition of a Bacterial DD-Peptidase by Peptidoglycan-Mimetic β-Lactams Helen R. Josephine, Ish Kumar, R. F. Pratt Journal of the American Chemical Society Antibacterial AgentsBioorganic ChemistryGlycobiologyStreptomyces R61 Dd-peptidaseAntimicrobial Chemotherapy	2004	43
Reactivity of Penicillin-Binding Proteins with Peptidoglycan-Mimetic β-Lactams: What's Wrong with These Enzymes? Helen R. Josephine, P. Charlier, Christopher Davies, Biochemistry	2006	43
Crystal Structures of Complexes of Bacterial dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle E. Sauvage, A.J. Powell, Jason Heilemann, Journal of Molecular Biology BiochemistryNatural SciencesPeptoidProtein X-ray CrystallographyMolecular Biology	2008	41
A Kinetic Alignment of Orthologous Inosine-5′-monophosphate Dehydrogenases Thomas V. Riera, Wen Wang, Helen R. Josephine, Biochemistry	2008	28
An Enzymatic Atavist Revealed in Dual Pathways for Water Activation Donghong Min, Helen R. Josephine, Hongzhi Li, PLoS Biology BiosynthesisCellular EnzymologyBiochemistryProton RelayProtein Folding	2008	24
Allosteric Activation via Kinetic Control: Potassium Accelerates a Conformational Change in IMP Dehydrogenase Thomas V. Riera, Lianqing Zheng, Helen R. Josephine, Biochemistry EngineeringClosed ConformationMolecular BiologyAllosteric ActivationImp Dehydrogenase	2011	22
The Cys319 Loop Modulates the Transition between Dehydrogenase and Hydrolase Conformations in Inosine 5′-Monophosphate Dehydrogenase Helen R. Josephine, Kanchana Ravichandran, Lizbeth Hedstrom Biochemistry	2010	10

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