Helen R. Josephine

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Justin A. Caravella, Jian Lin, R. Bruce Diebold et al. · Journal of Medicinal Chemistry · 2020 · 144 citations · Full text

Pharmacy, Oncology, Pharmacology +15

Crystal Structures of Complexes between the R61 DD-peptidase and Peptidoglycan-mimetic β-Lactams: A Non-covalent Complex with a “Perfect Penicillin”

N.R. Silvaggi, Helen R. Josephine, A.P. Kuzin et al. · Journal of Molecular Biology · 2004 · 61 citations

Life Sciences, Biology, Molecular Biology +14

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Jian Lin, Wei Lu, Justin A. Caravella et al. · Journal of Medicinal Chemistry · 2019 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The Perfect Penicillin? Inhibition of a Bacterial DD-Peptidase by Peptidoglycan-Mimetic β-Lactams

Helen R. Josephine, Ish Kumar, R. F. Pratt · Journal of the American Chemical Society · 2004 · 43 citations

Pharmacy, Medicinal Chemistry, Drug Design +9

Reactivity of Penicillin-Binding Proteins with Peptidoglycan-Mimetic β-Lactams:  What's Wrong with These Enzymes?

Helen R. Josephine, P. Charlier, Christopher Davies et al. · Biochemistry · 2006 · 43 citations · Full text

Life Sciences, Biochemistry, Microbiology +17