Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

Brandon W. Higgs, Zheng Liu, Barbara White, +9

Annals of the Rheumatic Diseases

Type I Interferon: Potential Therapeutic Target for Psoriasis?

Yihong Yao, Laura K. Richman, Chris Morehouse, +8

PLoS ONE

Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn’s Disease: A Phase 2a Study

Bruce E. Sands, Jingjing Chen, Brian G. Feagan, +14

Gastroenterology

Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer

Liyan Jiang, Jiaqi Huang, Brandon W. Higgs, +36

PLoS Genetics

EngineeringPathologyKey OncodriverCancer BiologyTumor Biology +15

Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

Susannah L. Hewitt, D. R. Shackleton Bailey, John Zielinski, +29

Clinical Cancer Research

Interferon‐stimulated gene 15 ( <i>ISG15</i> ) conjugates proteins in dermatomyositis muscle with perifascicular atrophy

Mohammad Salajegheh, Sek Won Kong, Jack L. Pinkus, +12

Annals of Neurology

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

Brandon W. Higgs, Wei Zhu, Chris Morehouse, +13

Annals of the Rheumatic Diseases

Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis

Steven A. Greenberg, Brandon W. Higgs, Chris Morehouse, +10

Genes and Immunity

ImmunodeficienciesImmunologyImmune RegulationDermatologyImmune System +20

Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus

Jeffrey M. Riggs, Richard N. Hanna, Bhargavi Rajan, +13

Lupus Science & Medicine

Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus

Yihong Yao, Brandon W. Higgs, Chris Morehouse, +9

Human Genomics and Proteomics

Clinical ImmunologyImmunohematologyImmunodeficienciesImmunologyWhole Blood +25