Tania Buck

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists

Mahmood Ahmed, Michael A. Briggs, Steven M. Bromidge et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Development of a P-Glycoprotein Knockout Model in Rodents to Define Species Differences in its Functional Effect at the Blood–brain Barrier

Leanne Cutler, Colin Howes, Nigel Deeks et al. · Journal of Pharmaceutical Sciences · 2006 · 44 citations

Medicine, Neuroscience, Pharmacology +17