NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

Luigi Franchi, Nobuhiko Kamada, Yuumi Nakamura, +6

Nature Immunology

InflammationIl-1β DiscriminatesMucosal ImmunologyMicrobial PathogensMedicine +11

Vacuolar and plasma membrane stripping and autophagic elimination of <i>Toxoplasma gondii</i> in primed effector macrophages

Yun M. Ling, Michael H. Shaw, Carol A. Ayala, +4

The Journal of Experimental Medicine

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

Michael H. Shaw, Nobuhiko Kamada, Kim Yun-Gi, +1

The Journal of Experimental Medicine

DysbiosisMicrobial PathogensHost-microbe InteractionsInnate Immune SystemImmunology +24

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

Yun‐Gi Kim, Jong‐Hwan Park, Michael H. Shaw, +3

Immunity

InflammationToll-like ReceptorsHost ResponsePathogenesisImmunology +9

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

Grace Chen, Michael H. Shaw, Gloria Redondo, +1

Cancer Research

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

Yun‐Gi Kim, Nobuhiko Kamada, Michael H. Shaw, +4

Immunity

InflammationCytokineAutoimmune DiseaseImmunologyInflammatory Monocytes +6

Nod1/RICK and TLR Signaling Regulate Chemokine and Antimicrobial Innate Immune Responses in Mesothelial Cells

Jong‐Hwan Park, Yun‐Gi Kim, Michael H. Shaw, +5

The Journal of Immunology

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

Michael H. Shaw, Thornik Reimer, Carmen Sánchez-Valdepeñas, +4

Nature Immunology

Type 1Autoimmune DiseaseAdaptive Immune SystemPathogenesisImmunology +12

Hedgehog Signaling Regulates Nociceptive Sensitization

Daniel T. Babcock, Shanping Shi, Ju-Yeon Jo, +3

Current Biology

Molecular NeurosciencePain MedicineMedicineNeuropathic PainMolecular Pain +5

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

Michael H. Shaw, Victor Boyartchuk, Sandy Wong, +6

Proceedings of the National Academy of Sciences