Identification of essential genes for cancer immunotherapy

Shashank J. Patel, Neville E. Sanjana, Rigel J. Kishton, +20

Nature

Tumor BiologyCancer ImmunosurveillanceImmunologyTumor ImmunityCancer Genomics +5

Ionic immune suppression within the tumour microenvironment limits T cell effector function

Robert Eil, Suman K. Vodnala, David Clever, +15

Nature

Ionic Immune SuppressionImmune EvasionCancer ImmunosurveillanceT-regulatory CellImmunology +9

T cell stemness and dysfunction in tumors are triggered by a common mechanism

Suman K. Vodnala, Robert Eil, Rigel J. Kishton, +16

Science

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

Laura Vera‐Ramirez, Suman K. Vodnala, Ryan Nini, +2

Nature Communications

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy

Christopher A. Klebanoff, Joseph G. Crompton, Anthony Leonardi, +16

JCI Insight

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

Tori N. Yamamoto, Ping‐Hsien Lee, Suman K. Vodnala, +15

Journal of Clinical Investigation

Tumor ImmunologyCancer ImmunosurveillanceT CellsT-regulatory CellImmunology +13

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

Devikala Gurusamy, Amanda N. Henning, Tori N. Yamamoto, +15

Cancer Cell

Off-target EffectImmunologyGene EditingGenome EditingImmune Cell Therapy +5

Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy

Eva Pérez‐Guijarro, Howard H. Yang, Romina E. Araya, +22

Nature Medicine

Tumor ImmunologyCancer ImmunosurveillanceMedicineMultimodel Preclinical PlatformMelanoma +10

Bioluminescent Imaging of Trypanosoma brucei Shows Preferential Testis Dissemination Which May Hamper Drug Efficacy in Sleeping Sickness

Filip Claes, Suman K. Vodnala, Nick Van Reet, +6

PLoS neglected tropical diseases

Antiparasitic AgentMalariaImmunologyPathologySleeping Sickness +14

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

Ping‐Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, +11

The Journal of Experimental Medicine