Prashant B. Nigade

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Neelima Sinha, Navnath P. Karche, Mahip Verma et al. · Journal of Medicinal Chemistry · 2019 · 25 citations · Full text

Pharmacy, Neuroscience, Pharmacology +15

Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

Prashant B. Nigade, Jayasagar Gundu, K. Sreedhara Ranganath Pai et al. · European Journal of Drug Metabolism and Pharmacokinetics · 2017 · 14 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Discovery of Potent, Selective, and State-Dependent Na_V1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure–Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides

Ramdas Vidya, Rashmi Talwar, Vijay Kanoje et al. · Journal of Medicinal Chemistry · 2020 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization

Navnath P. Karche, Mandar Bhonde, Neelima Sinha et al. · Bioorganic & Medicinal Chemistry · 2020 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of a Potent and Selective PI3Kδ Inhibitor (<i>S</i>)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4<i>H</i>-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

Manojkumar R. Shukla, Sukanya Patra, Mahip Verma et al. · Journal of Medicinal Chemistry · 2020 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9