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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Neelima Sinha, Navnath P. Karche, Mahip Verma, Sameer S. Walunj, Prashant B. Nigade, Gourhari Jana, Sanjay P. Kurhade, Anil K. Hajare, Ajay R. Tilekar, Ganesh R. Jadhav,

Journal of Medicinal Chemistry · 2019 · 25 citations · 28 references

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Abstract

has shown excellent safety profile in phase 1 clinical trials and is being evaluated for efficacy and safety as monotherapy in patients with mild to moderate Alzheimer's disease.

References

28

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