Concepedia

Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization

Navnath P. Karche, Mandar Bhonde, Neelima Sinha, Gourhari Jana, Gagan Kukreja, Sanjay P. Kurhade, Arun R. Jagdale, Ajay R. Tilekar, Anil K. Hajare, Ganesh R. Jadhav,

Bioorganic & Medicinal Chemistry · 2020 · 13 citations · 18 references

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18

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai, Shar-yin N. Huang, Benu Brata Das et al. · Cancer Research · 2012 · 2.2K citations · Full text

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(ADP-ribose)n participates in DNA excision repair

Barbara W. Durkacz, Olusesan Omidiji, Douglas A. Gray et al. · Nature · 1980 · 1.1K citations

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4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith Menear, Claire Adcock, Robert Boulter et al. · Journal of Medicinal Chemistry · 2008 · 586 citations · Full text

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Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-Ribosylation

H. O. Kleine, Elżbieta Poręba, Krzysztof Leśniewicz et al. · Molecular Cell · 2008 · 353 citations · Full text

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Discovery of 2-{4-[(3<i>S</i>)-Piperidin-3-yl]phenyl}-2<i>H</i>-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

Philip Jones, Sergio Altamura, Julia K. Boueres et al. · Journal of Medicinal Chemistry · 2009 · 315 citations · Full text

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