The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

Ji‐Yeun Hur, Georgia Frost, Xianzhong Wu, +28

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineImmune RegulationImmunology +6

ADAM17 substrate release in proximal tubule drives kidney fibrosis

Eirini Kefaloyianni, Muthu Lakshmi Muthu, Jakob Kaeppler, +11

JCI Insight

Renal PathologyImmunologyRenal InflammationPathologyImmune Regulation +22

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

Eitan Wong, Thorsten Maretzky, Yoav Peleg, +2

Journal of Biological Chemistry

Protein ExpressionCleavage SiteProtein FoldingGeneticsA Disintegrin +6

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

Eitan Wong, Tal Cohen, Erez Romi, +6

Scientific Reports

GSAP modulates γ-secretase specificity by inducing conformational change in PS1

Eitan Wong, George P. Liao, Jerry C. Chang, +3

Proceedings of the National Academy of Sciences

Development of a clinical-scale method for generation of dendritic cells from PBMC for use in cancer immunotherapy

Eitan Wong, V. Ellen Maher, Kenneth Hines, +7

Cytotherapy

Cancer ImmunosurveillanceClinical-scale MethodMedicineImmunologyImmunoediting +9

Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion

Courtney Alexander, Thomas Li, Yorito Hattori, +9

Molecular Psychiatry

Aβ ProductionNeurophysiologyPhysiologyCerebral HypoperfusionHypoxia (Medicine) +10

ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

Erez Romi, Irena Gokhman, Eitan Wong, +6

Nature Communications

Signal TransductionDevelopmental BiologyDevelopmental GeneticsMetalloproteinAxonal Repellant Sema3a +5

Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling

Hua Liu, Fang Mei, Wenli Yang, +8

Science Advances

Optical Nanosensor for Intracellular and Intracranial Detection of Amyloid-Beta

Merav Antman‐Passig, Eitan Wong, Georgia Frost, +10

ACS Nano