Vaishali Patel

Prolonged and tunable residence time using reversible covalent kinase inhibitors

J. Michael Bradshaw, Jesse M. McFarland, Ville O. Paavilainen et al. · Nature Chemical Biology · 2015 · 422 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +5

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

Michael Soth, Johannes C. Hermann, Calvin Yee et al. · Journal of Medicinal Chemistry · 2012 · 66 citations · Full text

Drug Target, Janus Kinases, Immunology +21

Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome

Stephen M. Lynch, Javier DeVicente, Johannes C. Hermann et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 33 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +11

Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors

Saul Jaime‐Figueroa, Javier de Vicente, Johannes C. Hermann et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 32 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +7

Scaffold hopping towards potent and selective JAK3 inhibitors: Discovery of novel C-5 substituted pyrrolopyrazines

Javier de Vicente, Rémy C. Lemoine, Mark J. Bartlett et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 22 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9