Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Derek M. Mason, Simon Friedensohn, Cédric R. Weber, +9

Nature Biomedical Engineering

EngineeringMachine LearningDeep LearningMedicineArtificial Immune System +10

Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain

Joseph M. Taft, Cédric R. Weber, Beichen Gao, +8

Cell

Viral PathogenesisImmunologyMolecular BiologyViral Structural ProteinBroad-spectrum Vaccines +14

Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study

Daniel J. Sheward, Chang-Il Kim, Roy A. Ehling, +9

The Lancet Infectious Diseases

Neutralisation SensitivityCovid-19Sars-cov-2 OmicronRadiologyCross-sectional Study

A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients

Florian Bieberich, Rodrigo Vazquez-Lombardi, Alexander Yermanos, +9

Frontiers in Immunology

High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing

Duran Sürün, Joachim Schwäble, Ana Tomasovic, +5

Molecular Therapy — Nucleic Acids

Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells

Theresa Pesch, Lucia Bonati, William Kelton, +5

Frontiers in Immunology

EngineeringSynthetic CbcrImmunologyAntigen ProcessingImmune Cell Therapy +17

Evasion of neutralizing antibodies by Omicron sublineage BA.2.75

Daniel J. Sheward, Chang-Il Kim, Julian Fischbach, +8

ImmunohematologyViral DiagnosticsImmunodeficienciesHumoral ResponseImmunology +14

Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells

Daniel Neumeier, Alexander Yermanos, Andreas Agrafiotis, +12

Proceedings of the National Academy of Sciences

SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display

Roy A. Ehling, Cédric R. Weber, Derek M. Mason, +17

Cell Reports

Neutralizing AntibodiesSars-cov-2 ReactiveViral DiagnosticsViral PathogenesisImmunology +14

Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single‐cell analysis

Daniel Neumeier, Alessandro Pedrioli, Alessandro Genovese, +16

European Journal of Immunology